Principles of Drug Discovery [MPL203T] Second Semester,Master of Pharmacy (Pharmacology), June-2021 Paper

Master of Pharmacy (Pharmacology)

Second Semester Examination, June-2021

Principles of Drug Discovery [MPL203T]

Time: 3:00 Hrs Max Marks 75

Note: Attempt any five questions. All questions carry equal marks.

Q.1 (a) What are Virtual Screening techniques, describe Drug likeness screening.

(b) Describe the concept of pharmacophore mapping and pharmacophore based approaches.

Q.2 (a) Describe in detail docking based screening.

(b) Write a note on history and development of QSAR, SAR versus QSAR.

Q.3 (a) Describe pro-drug to improve patient acceptability,

(b) Describe in detail drug solubility, drug absorption and distribution.

Q.4 (a) What is Molecular docking, describe rigid docking, flexible docking and manual docking techniques.

(b) Describe physicochemical parameters, Hansch analysis, Fee Wilson analysis and relationship between them.

Q.5 (a) Describe De novo drug design, in detail.

(b) Write a role of Genomics, Proteomics and Bioinformatics in Target Discovery and validation.

Q.6 (a) Describe 3D-QSAR approaches like COMFA and COMSIA and Pro-drug design- Basic concept.

(b) Rationale of pro-drug design and practical consideration of prodrug design.

Q.7 (a) Write down the application of NMR and X-ray crystallography in protein structure prediction

(b) Write a note on Threading and homology modeling methods.

Q.8 (a) What are quantitative analysis of Structure Activity Relationship.

(b) Write the Protein structure Levels of protein structure in detail.

Principles-of-Drug-Discovery-[MPL203T]-Paper